CILIOTOXICITY OF METHYL-P-HYDROXYBENZOATES AND PROPYL-P-HYDROXYBENZOATES - A DOSE-RESPONSE AND SURFACE-RESPONSE STUDY

被引：8

作者：

JIAN, L ^{[1
]}

PO, ALW ^{[1
]}

机构：

[1] QUEENS UNIV BELFAST,SCH PHARM,DRUG DELIVERY RES GRP,97 LISBURN RD,BELFAST BT9 7BL,ANTRIM,NORTH IRELAND

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1993年 / 45卷 / 10期

关键词：

D O I：

10.1111/j.2042-7158.1993.tb05624.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of methyl-p-hydroxybenzoate (methyl paraben, MHB) and propyl-p-hydroxybenzoate (propyl paraben, PHB) on ciliary beat frequency was investigated using surface-response methodology. Both compounds are shown to be ciliotoxic at concentrations equal to or lower than those in use for preserving aqueous formulations. The dose-response curves show the typical sigmoidal pattern. Interaction by the two compounds is evidenced by the curved response surface for ciliotoxicity.

引用

页码：925 / 927

页数：3

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