AGMATINE TREATMENT IS NEUROPROTECTIVE IN RODENT BRAIN INJURY MODELS

被引：57

作者：

GILAD, GM ^{[1
]}

SALAME, K ^{[1
]}

RABEY, JM ^{[1
]}

GILAD, VH ^{[1
]}

机构：

[1] TEL AVIV SOURASKY MED CTR,DEPT NEUROSURG,IL-64239 TEL AVIV,ISRAEL

来源：

LIFE SCIENCES | 1995年 / 58卷 / 02期

关键词：

CELL DEATH; ISCHEMIA; NEURONAL CULTURES; N-METHYL-D-ASPARTATE; POLYAMINES;

D O I：

10.1016/0024-3205(95)02274-0

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Agmatine is a naturally occurring guanidino compound, found in bacteria and plants, with several proposed nervous system-related functions suggestive of beneficial effects in central nervous system injury. Here evidence is presented that agmatine can exert potent neuroprotection in both in vitro and in vivo rodent models of neurotoxic and ischemic brain injuries. The cumulative evidence lead us to suggest that agmatine, a relatively nontoxic compound, be tried for potential therapeutic use after neurotrauma and in neurodegenerative disorders.

引用

页码：PL41 / PL46

页数：6

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