GLUTATHIONE PREVENTS ETHANOL INDUCED GASTRIC-MUCOSAL DAMAGE AND DEPLETION OF SULFHYDRYL COMPOUNDS IN HUMANS

被引：83

作者：

LOGUERCIO, C

TARANTO, D

BENEDUCE, F

BLANCO, CD

DEVINCENTIIS, A

NARDI, G

ROMANO, M

机构：

[1] UNIV NAPLES,SCH MED 1,DEPT INTERNAL MED GASTROINTESTINAL PATHOPHYSIOL,I-80138 NAPLES,ITALY

[2] BOEHRINGER SPA,MANNHEIM,GERMANY

[3] STAZ BIOL A DHORN,BIOCHEM LAB,NAPLES,ITALY

[4] UNIV NAPLES,SCH MED 1,INST GEN MED & CLIN METHODOL,I-80138 NAPLES,ITALY

来源：

GUT | 1993年 / 34卷 / 02期

关键词：

D O I：

10.1136/gut.34.2.161

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Whether parenteral administration of reduced glutathione prevented ethanol induced damage to and depletion of sulfhydryl compounds in the human gastric mucosa was investigated. Ten healthy volunteers underwent endoscopy on three separate occasions. Gastric mucosal damage was induced by spraying 80% ethanol on to the gastric mucosa through the biopsy channel of the endoscope. The gastric mucosal score, total sulfhydryls, glutathione, and cysteine were evaluated in basal conditions and after ethanol administration with and without pretreatment with parenteral glutathione. Glulathione significantly decreased the extent of ethanol induced macroscopic injury to the mucosa of the gastric body and antrum. Glutathione's protective effect is associated with appreciable inhibition of ethanol induced depletion of gastric sulfhydryl compounds. This is the first report of protection against ethanol induced gastric mucosal damage by a sulfhydryl containing agent in humans.

引用

页码：161 / 165

页数：5

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[31] SULFHYDRYLS PROTECT PATIENTS AGAINST COMPLICATIONS OF EROSIVE GASTRITIS [J].