Using Network Biology to Bridge Pharmacokinetics and Pharmacodynamics in Oncology

被引：20

作者：

Kirouac, D. C. ^{[1
]}

Onsum, M. D. ^{[2
]}

机构：

[1] Merrimack Pharmaceut Inc, Cambridge, MA 02139 USA

[2] Silver Creek Pharmaceut Inc, San Francisco, CA USA

来源：

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY | 2013年 / 2卷 / 09期

关键词：

D O I：

10.1038/psp.2013.38

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

If mathematical modeling is to be used effectively in cancer drug development, future models must take into account both the mechanistic details of cellular signal transduction networks and the pharmacokinetics (PK) of drugs used to inhibit their oncogenic activity. In this perspective, we present an approach to building multiscale models that capture systems-level architectural features of oncogenic signaling networks, and describe how these models can be used to design combination therapies and identify predictive biomarkers in silico.

引用

页数：7

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