EFFECTS OF MPTP, MPP+, AND PARAQUAT ON NADPH-DEPENDENT LIPID-PEROXIDATION IN MOUSE-BRAIN AND LUNG MICROSOMES

被引：4

作者：

HARA, S

ENDO, T

KURIIWA, F

KANO, S

机构：

[1] Department of Forensic Medicine, Tokyo Medical College, Shinjuku-ku, Tokyo, 160, 1-1

来源：

BIOCHEMICAL MEDICINE AND METABOLIC BIOLOGY | 1991年 / 45卷 / 03期

关键词：

D O I：

10.1016/0885-4505(91)90033-H

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Both MPTP and MPP+ inhibited the NADPH-dependent microsomal LPO in mouse brain and lung. On the other hand, PQ significantly stimulated the LPO in brain microsomes in a dose-dependent manner. The herbicide, however, stimulated lung microsomal LPO only in a narrow concentration range, despite much higher P450 reductase activity in lung microsomes than that in brain microsomes. These findings suggest that the effect of PQ on microsomal LPO is different from those of the analogous neurotoxins, MPTP and MPP+, and is not uniform in brain and lung. © 1991.

引用

收藏

页码：292 / 297

页数：6

相关论文

共 28 条

[1] INDUCTION BY 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE OF LIPID-PEROXIDATION INVIVO IN VITAMIN-E DEFICIENT MICE [J].

ADAMS, JD ;

ODUNZE, IN ;

SEVANIAN, A .

BIOCHEMICAL PHARMACOLOGY, 1990, 39 (01) :R5-R8

[2] STRUCTURE-NEUROTOXICITY TRENDS OF ANALOGS OF 1-METHYL-4-PHENYLPYRIDINIUM (MPP+), THE CYTOTOXIC METABOLITE OF THE DOPAMINERGIC NEUROTOXIN MPTP [J].

ARORA, PK ;

RIACHI, NJ ;

FIEDLER, GC ;

SINGH, MP ;

ABDALLAH, F ;

HARIK, SI ;

SAYRE, LM .

LIFE SCIENCES, 1990, 46 (05) :379-390

[3] SUPEROXIDE-CATALYZED AND SINGLET OXYGEN-CATALYZED LIPID PEROXIDATION AS A POSSIBLE MECHANISM FOR PARAQUAT (METHYL VIOLOGEN) TOXICITY [J].

BUS, JS ;

GIBSON, JE ;

AUST, SD .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1974, 58 (03) :749-755

[4] PARAQUAT - MODEL FOR OXIDANT-INITIATED TOXICITY [J].

BUS, JS ;

GIBSON, JE .

ENVIRONMENTAL HEALTH PERSPECTIVES, 1984, 55 (APR) :37-46

[5] MPTP FAILS TO INDUCE LIPID-PEROXIDATION INVIVO [J].

CORONGIU, FP ;

DESSI, MA ;

BANNI, S ;

BERNARDI, F ;

PICCARDI, MP ;

DELZOMPO, M ;

CORSINI, GU .

BIOCHEMICAL PHARMACOLOGY, 1987, 36 (14) :2251-2253

[6]

ENDO T, 1988, RES COMMUN PSYCH PSY, V13, P261

[7] MODEL STUDY ON THE BIOREDUCTION OF PARAQUAT, MPP+, AND ANALOGS - EVIDENCE AGAINST A REDOX CYCLING MECHANISM IN MPTP NEUROTOXICITY [J].

FRANK, DM ;

ARORA, PK ;

BLUMER, JL ;

SAYRE, LM .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 147 (03) :1095-1104

[8] 1-METHYL-4-PHENYLPYRIDINE (MPP+) INDUCES OXIDATIVE STRESS IN THE RODENT [J].

JOHANNESSEN, JN ;

ADAMS, JD ;

SCHULLER, HM ;

BACON, JP ;

MARKEY, SP .

LIFE SCIENCES, 1986, 38 (08) :743-749

[9] MPTP TOXICITY - IMPLICATIONS FOR RESEARCH IN PARKINSONS-DISEASE [J].

KOPIN, IJ ;

MARKEY, SP .

ANNUAL REVIEW OF NEUROSCIENCE, 1988, 11 :81-96

[10]

Litchfield M H, 1973, Toxicology, V1, P155, DOI 10.1016/0300-483X(73)90029-2