INTERSPECIES SCALING OF ANESTHETIC POTENCY

被引：19

作者：

TRAVIS, CC

BOWERS, JC

机构：

[1] Risk Analysis Section Health and Safety Research Division, Oak Ridge National Laboratory, Oak Ridge

来源：

TOXICOLOGY AND INDUSTRIAL HEALTH | 1991年 / 7卷 / 04期

关键词：

D O I：

10.1177/074823379100700402

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Anesthetic potency data for 11 volatile anesthetics were correlated against body weight in multiple mammalian species, including man. The results indicate that the alveolar concentration necessary to produce anesthesia is approximately constant across species. Because alveolar ventilation rates scale with the 0.75 power of body weight, this implies that administered dose measured in mg/kg0.75/day produces the same anesthetic effect in all species. This analysis provides further support for the use of a mg/kg0.75/day interspecies scaling metric for acute toxic effects.

引用

页码：249 / 260

页数：12