ROLE OF TYROSINE KINASES IN LYMPHOCYTE-ACTIVATION - TARGETS FOR DRUG INTERVENTION

被引：18

作者：

HANKE, JH

POLLOK, BA

CHANGELIAN, PS

机构：

[1] Pfizer Central Research, Groton, 06340, CT, Eastern Point Rd.

来源：

INFLAMMATION RESEARCH | 1995年 / 44卷 / 09期

关键词：

TYROSINE KINASES; LYMPHOCYTES; DRUG TARGETS;

D O I：

10.1007/BF01797862

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent developments in our understanding of lymphocyte receptor-associated signalling events have offered many new potential targets for modifying antigen and cytokine receptor signalling events in immune-related diseases such as allergy, autoimmunity and transplant rejection. As discussed below, these targets are largely tissue-restricted and are functionally confined to a limited set of receptors. Therefore, it is anticipated that selective inhibitors of these signalling events would offer safe and effective therapies for immunologically-based diseases. First, we review T and B cell antigen receptor signalling as targets for inhibiting lymphocyte responses. Second, targets in lymphocyte cytokine receptor signalling pathways are discussed. Finally, we review strategies for inhibition of receptor signalling.

引用

收藏

页码：357 / 371

页数：15

相关论文

共 189 条

[1]

AKIYAMA T, 1987, J BIOL CHEM, V262, P5592

[2] CD28-B7 INTERACTIONS IN T-CELL ACTIVATION [J].

ALLISON, JP .

CURRENT OPINION IN IMMUNOLOGY, 1994, 6 (03) :414-419

[3] MUTATION OF A SITE OF TYROSINE PHOSPHORYLATION IN THE LYMPHOCYTE-SPECIFIC TYROSINE PROTEIN-KINASE, P56LCK, REVEALS ITS ONCOGENIC POTENTIAL IN FIBROBLASTS [J].

AMREIN, KE ;

SEFTON, BM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (12) :4247-4251

[4] DEFECTIVE T-CELL RECEPTOR SIGNALING IN MICE LACKING THE THYMIC ISOFORM OF P59(FYN) [J].

APPLEBY, MW ;

GROSS, JA ;

COOKE, MP ;

LEVIN, SD ;

QIAN, X ;

PERLMUTTER, RM .

CELL, 1992, 70 (05) :751-763

[5] IDENTIFICATION OF JAK2 AS A GROWTH-HORMONE RECEPTOR-ASSOCIATED TYROSINE KINASE [J].

ARGETSINGER, LS ;

CAMPBELL, GS ;

YANG, XN ;

WITTHUHN, BA ;

SILVENNOINEN, O ;

IHLE, JN ;

CARTERSU, C .

CELL, 1993, 74 (02) :237-244

[6] DEFECTIVE T-CELL RECEPTOR SIGNALING AND CD8(+) THYMIC SELECTION IN HUMANS LACKING ZAP-70 KINASE [J].

ARPAIA, E ;

SHAHAR, M ;

DADI, H ;

COHEN, A ;

ROIFMAN, CM .

CELL, 1994, 76 (05) :947-958

[7] EVIDENCE THAT GENISTEIN, A PROTEIN-TYROSINE KINASE INHIBITOR, INHIBITS CD28 MONOCLONAL-ANTIBODY-STIMULATED HUMAN T-CELL PROLIFERATION [J].

ATLURU, S ;

ATLURU, D .

TRANSPLANTATION, 1991, 51 (02) :448-450

[8] CD28 IS ASSOCIATED WITH AND INDUCES THE IMMEDIATE TYROSINE PHOSPHORYLATION AND ACTIVATION OF THE TEC FAMILY KINASE ITK/EMT IN THE HUMAN JURKAT LEUKEMIC T-CELL LINE [J].

AUGUST, A ;

GIBSON, S ;

KAWAKAMI, Y ;

KAWAKAMI, T ;

MILLS, GB ;

DUPONT, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (20) :9347-9351

[9] B70 ANTIGEN IS A 2ND LIGAND FOR CTLA-4 AND CD28 [J].

AZUMA, M ;

ITO, D ;

YAGITA, H ;

OKUMURA, K ;

PHILLIPS, JH ;

LANIER, LL ;

SOMOZA, C .

NATURE, 1993, 366 (6450) :76-79

[10] DISSECTION OF T-CELL ANTIGEN RECEPTOR SIGNALING USING PROTEIN-TYROSINE KINASE INHIBITORS [J].

BALDARI, CT ;

TELFORD, JL .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1994, 24 (05) :1046-1052

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