ROLE OF TYROSINE KINASES IN LYMPHOCYTE-ACTIVATION - TARGETS FOR DRUG INTERVENTION

被引：18

作者：

HANKE, JH

POLLOK, BA

CHANGELIAN, PS

机构：

[1] Pfizer Central Research, Groton, 06340, CT, Eastern Point Rd.

来源：

INFLAMMATION RESEARCH | 1995年 / 44卷 / 09期

关键词：

TYROSINE KINASES; LYMPHOCYTES; DRUG TARGETS;

D O I：

10.1007/BF01797862

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent developments in our understanding of lymphocyte receptor-associated signalling events have offered many new potential targets for modifying antigen and cytokine receptor signalling events in immune-related diseases such as allergy, autoimmunity and transplant rejection. As discussed below, these targets are largely tissue-restricted and are functionally confined to a limited set of receptors. Therefore, it is anticipated that selective inhibitors of these signalling events would offer safe and effective therapies for immunologically-based diseases. First, we review T and B cell antigen receptor signalling as targets for inhibiting lymphocyte responses. Second, targets in lymphocyte cytokine receptor signalling pathways are discussed. Finally, we review strategies for inhibition of receptor signalling.

引用

页码：357 / 371

页数：15

共 189 条

[21] THE CONSERVED LYSINE OF THE CATALYTIC DOMAIN OF PROTEIN-KINASES IS ACTIVELY INVOLVED IN THE PHOSPHOTRANSFER REACTION AND NOT REQUIRED FOR ANCHORING ATP [J].