TOPOGRAPHIC ORGANIZATION OF SENSORY PROJECTIONS TO THE OLFACTORY-BULB

被引：993

作者：

VASSAR, R ^{[1
]}

CHAO, SK ^{[1
]}

SITCHERAN, R ^{[1
]}

NUNEZ, JM ^{[1
]}

VOSSHALL, LB ^{[1
]}

AXEL, R ^{[1
]}

机构：

[1] COLUMBIA UNIV,COLL PHYS & SURG,HOWARD HUGHES MED INST,NEW YORK,NY 10032

来源：

CELL | 1994年 / 79卷 / 06期

关键词：

D O I：

10.1016/0092-8674(94)90029-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The detection of odorant receptor mRNAs within the axon terminals of sensory neurons has permitted us to ask whether neurons expressing a given receptor project their axons to common glomeruli within the olfactory bulb. In situ hybridization with five different receptor probes demonstrates that axons from neurons expressing a given receptor converge on one, or at most, a few glomeruli within the olfactory bulb. Moreover, the position of specific glomeruli is bilaterally symmetric and is constant in different individuals within a species. These data support a model in which exposure to a given odorant may result in the stimulation of a spatially restricted set of glomeruli, such that the individual odorants would be associated with specific topographic patterns of activity within the olfactory bulb.

引用

页码：981 / 991

页数：11

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