NADH MODELS IN THE PYRROLO[3,4-B]PYRIDINE SERIES - ROLE OF THE CYCLIZED STRUCTURE IN THE STEREOCONTROL OF REDUCTIONS

被引：19

作者：

BEDAT, J ^{[1
]}

LEVACHER, V ^{[1
]}

DUPAS, G ^{[1
]}

QUEGUINER, G ^{[1
]}

BOURGUIGNON, J ^{[1
]}

机构：

[1] INST NATL SCI APPL, IRCOF,CHIM ORGAN FINE & HETEROCYCL LAB,CNRS, URA 1429, F-76131 MONT ST AIGNAN, FRANCE

来源：

CHEMISTRY LETTERS | 1995年 / 04期

关键词：

D O I：

10.1246/cl.1995.327

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis of a chiral NADH model in pyrrolo[3,4-b] pyridine series is described and the asymmetric reduction of methyl benzoylformate is studied. Its asymmetric behavior compared with a cyclized analogue in naphthyridine series suggests that the orientation of the carbonyl group of the lactam plays an important role in the stereochemical control of the reduction.

引用

页码：327 / 328

页数：2

共 18 条

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