NADH MODELS IN THE PYRROLO[3,4-B]PYRIDINE SERIES - ROLE OF THE CYCLIZED STRUCTURE IN THE STEREOCONTROL OF REDUCTIONS

被引:19
作者
BEDAT, J [1 ]
LEVACHER, V [1 ]
DUPAS, G [1 ]
QUEGUINER, G [1 ]
BOURGUIGNON, J [1 ]
机构
[1] INST NATL SCI APPL, IRCOF,CHIM ORGAN FINE & HETEROCYCL LAB,CNRS, URA 1429, F-76131 MONT ST AIGNAN, FRANCE
关键词
D O I
10.1246/cl.1995.327
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The synthesis of a chiral NADH model in pyrrolo[3,4-b] pyridine series is described and the asymmetric reduction of methyl benzoylformate is studied. Its asymmetric behavior compared with a cyclized analogue in naphthyridine series suggests that the orientation of the carbonyl group of the lactam plays an important role in the stereochemical control of the reduction.
引用
收藏
页码:327 / 328
页数:2
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