HLA ANTIGENS AND HAPLOTYPES ASSOCIATED WITH IDIOPATHIC HEMOCHROMATOSIS IN VENETO - PECULIAR ASSOCIATION WITH HLA-A3,B35

被引：5

作者：

DEMENIS, E

BREDA, F

MONCO, A

FOSCOLO, G

LEGOVINI, P

SCALDAFERRI, E

MORO, L

CONTE, N

机构：

[1] OSPED REG TREVISO,CTR ANTIDIABET,I-31100 TREVISO,ITALY

[2] OSPED REG TREVISO,SERV TRASFUS & IMMUNOEMATOL,I-31100 TREVISO,ITALY

来源：

ACTA HAEMATOLOGICA | 1990年 / 83卷 / 03期

关键词：

HLA antigens; HLA haplotypes; Idiopathic haemochromatosis; Linkage disequilibrium;

D O I：

10.1159/000205184

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

HLA-A and HLA-B antigens were determined in 16 unrelated subjects orginating from Veneto affected by idiopathic haemochromatosis (IH). HLA-A3 was found in 13/16 patients vs. 300/1, 348 controls (p < 0.00005). Prevalences of A3, B35 haplotype were 0.4375 in patients vs. 0.0816 in controls (p < 0.0005). Linkage disequilibrium analysis proved the existence of a positive third-order linkage disequilibrium among IH, HLA-A3 and HLA-B35 alleles. Our data confirm the close association of IH and HLA-A3 and prove the peculiar association of the disease with A3, B35 haplotype in north-eastern regions of Italy. The positive third-order linkage disequilibrium suggests a remote event (mutation, recombination or immigration) as origin for 1H and A3, B35 association. © 1990 S. Karger AG, Basel.

引用

页码：113 / 115

页数：3