EP-CAM - A HOMOPHILIC CELL-CELL ADHESION MOLECULE WITH EGF-LIKE DOMAINS

被引:9
作者
LITVINOV, SV [1 ]
机构
[1] LEIDEN UNIV, DEPT PATHOL, 2300 RC LEIDEN, NETHERLANDS
关键词
CELL ADHESION; EGF-LIKE DOMAINS; EP-CAM; EPITHELIUM; GA733-2;
D O I
10.4052/tigg.7.375
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Ep-CAM is a recently identified Ca2+-independent, hemophilic cell-cell adhesion molecule of epithelial cells. This transmembrane glycoprotein has a molecular weight of only 40 kD, which is unusually small for an adhesion protein. The extracellular domain of Ep-CAM contains two EGF-like domains followed by a cysteine-poor region- structural features that set Ep-CAM apart-from, the four main groups of cell adhesion molecules - cadherins, integrins, selectins and adhesion molecules of the immunoglobulin superfamily. Ep-CAM is abundantly expressed in simple, transitional and some pseudostratified epithelia, but not in squamous epithelia, where the de novo expression of this molecule is often associated with proliferative/neoplastic changes. Ep-CAM is not expressed in cell types of nonepithelial origin. The exact biological role of the Ep-CAM molecule is still unknown, but the evidence so far suggests involvement in regulation of cell-cell interactions, segregation of cell types, tissue pattern formation, and support of tissue architecture.
引用
收藏
页码:375 / 384
页数:10
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