THE MOLECULAR-BASIS OF MOISTURE EFFECTS ON THE PHYSICAL AND CHEMICAL-STABILITY OF DRUGS IN THE SOLID-STATE

被引：423

作者：

AHLNECK, C ^{[1
]}

ZOGRAFI, G ^{[1
]}

机构：

[1] UNIV WISCONSIN, SCH PHARM, MADISON, WI 53706 USA

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1990年 / 62卷 / 2-3期

关键词：

Crystal defect; Drug-excipient interaction; Glass transition; Moisture sorption; Molecular mobility; Solid-state degradation; Solid-state transition; Water sorption;

D O I：

10.1016/0378-5173(90)90221-O

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

[No abstract available]

引用

页码：87 / 95

页数：9

共 61 条

[31] RELATIONSHIP BETWEEN ADSORPTION OF WATER-VAPOR ON GROUND SODIUM-CHLORIDE AND CAKING OF SALT [J].

KAIHO, M ;

CHIKAZAW.M ;

KANAZAWA, T .

NIPPON KAGAKU KAISHI, 1974, (02) :233-238

[32] INFLUENCE OF ADSORBED WATER ON SURFACE STATE OF SODIUM-CHLORIDE POWDER [J].

KAIHO, M ;

CHIKAZAW.M ;

KANAZAWA, T .

NIPPON KAGAKU KAISHI, 1973, (05) :914-917

[33] SOLID-STATE INTERACTION OF MAGNESIUM-OXIDE AND IBUPROFEN TO FORM A SALT [J].

KARARLI, TT ;

NEEDHAM, TE ;

SEUL, CJ ;

FINNEGAN, PM .

PHARMACEUTICAL RESEARCH, 1989, 6 (09) :804-808

[34]

KNACKE O, 1970, Z PHYS CHEM NEUE FOL, V71, P247

[35] GELATIN CAPSULE BRITTLENESS AS A FUNCTION OF RELATIVE-HUMIDITY AT ROOM-TEMPERATURE [J].

KONTNY, MJ ;

MULSKI, CA .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1989, 54 (01) :79-85

[36] WATER-VAPOR SORPTION OF WATER-SOLUBLE SUBSTANCES - STUDIES OF CRYSTALLINE SOLIDS BELOW THEIR CRITICAL RELATIVE HUMIDITIES [J].

KONTNY, MJ ;

GRANDOLFI, GP ;

ZOGRAFI, G .

PHARMACEUTICAL RESEARCH, 1987, 4 (02) :104-112

[37] DECOMPOSITION OF ASPIRIN IN THE SOLID STATE [J].

LEESON, LJ ;

MATTOCKS, AM .

JOURNAL OF THE AMERICAN PHARMACEUTICAL ASSOCIATION, 1958, 47 (05) :329-333

[38] THERMOMECHANICAL PROPERTIES OF SMALL-CARBOHYDRATE WATER GLASSES AND RUBBERS - KINETICALLY METASTABLE SYSTEMS AT SUB-ZERO TEMPERATURES [J].

LEVINE, H ;

SLADE, L .

JOURNAL OF THE CHEMICAL SOCIETY-FARADAY TRANSACTIONS I, 1988, 84 :2619-2633

[39]

Levine H., 1987, WATER SCI REV, V3, P79

[40] MECHANISM OF HARDNESS OF AGED COMPACTS [J].

LORDI, N ;

SHIROMANI, P .

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1984, 10 (05) :729-752

← 1 2 3 4 5 6 7 →