ERYTHROPOIETIN ACTION IN RAT MARROW CELL-CULTURES IN COMPLETE ABSENCE OF DNA-SYNTHESIS .2. LONG-TERM EFFECTS ON MACROMOLECULAR-SYNTHESIS

被引：1

作者：

DATTA, MC

DUKES, PP

机构：

[1] CHILDRENS HOSP LOS ANGELES, DIV HEMATOL ONCOL, LOS ANGELES, CA 90027 USA

[2] UNIV SO CALIF, SCH MED, LOS ANGELES, CA 90027 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1976年 / 69卷 / 02期

关键词：

D O I：

10.1016/0006-291X(76)90548-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rat marrow cells were preincubated for 45 h with 5.5 .times. 10-4 M sodium hexachloroiridate. This treatment abolished DNA synthesis while improving cell survival over that of controls. The synthesis of RNA, protein and glycoprotein continued and could be further increased by the addition of erythropoietin for up to 44 more h. Heme synthesis also continued in the absence of DNA synthesis but could not be stimulated by erythropoietin.

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收藏

页码：489 / 498

页数：10

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