HIGH-SENSITIVITY ASSAY FOR THE ALPHA-2-ANTAGONIST 6-CHLORO-3-METHYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE AND ITS DESMETHYL METABOLITE IN PLASMA USING GAS-CHROMATOGRAPHY MASS-SPECTROMETRY WITH AMMONIA CCL4 CHEMICAL IONIZATION

被引：6

作者：

LEVANDOSKI, P

STRAUB, K

SHAH, D

DEMARINIS, R

DEMEY, C

机构：

[1] SK&F LABS,DEPT DRUG METAB,SWEDELAND,PA 19479

[2] SK&F LABS,DEPT MED CHEM,SWEDELAND,PA 19479

[3] SMITH KLINE DAUELSBERG GMBH,SK&F INST APPL CLIN PHARMACOL,GOTTINGEN,FED REP GER

来源：

BIOMEDICAL AND ENVIRONMENTAL MASS SPECTROMETRY | 1986年 / 13卷 / 10期

关键词：

D O I：

10.1002/bms.1200131002

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

引用

页码：523 / 530

页数：8

共 7 条

[1] 6-CHLORO-2,3,4,5-TETRAHYDRO-3-METHYL-1H-3-BENZAZEPINE - A POTENT AND SELECTIVE ANTAGONIST OF ALPHA-2-ADRENOCEPTORS [J].

DEMARINIS, RM ;

HIEBLE, JP ;

MATTHEWS, WD .

JOURNAL OF MEDICINAL CHEMISTRY, 1983, 26 (09) :1213-1214

[2]

FENG T, 1982, 30TH P ANN C MASS SP, P525

[3]

FOLTZ RL, 1983, 31ST P ANN C MASS SP, P454

[4] FACTORS AFFECTING REACTIVITY IN AMMONIA CHEMICAL IONIZATION MASS-SPECTROMETRY [J].

KEOUGH, T ;

DESTEFANO, AJ .

ORGANIC MASS SPECTROMETRY, 1981, 16 (12) :527-533

[5] EFFECT OF ELECTRON-CAPTURE AGENTS IN CHEMICAL IONIZATION MASS-SPECTROMETRY [J].

RUDEWICZ, P ;

FENG, T ;

BLOM, K ;

MUNSON, B .

ANALYTICAL CHEMISTRY, 1984, 56 (13) :2610-2611

[6]

RUDEWICZ P, 1984, 32ND P ANN C MASS SP, P178

[7]

STRAUB K, 1984, 32ND ANN C MASS SPEC, P785

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