BRAIN LITHIUM CONCENTRATION BY LI-7-MAGNETIC AND H-1-MAGNETIC RESONANCE SPECTROSCOPY IN BIPOLAR DISORDER

被引：51

作者：

KATO, T ^{[1
]}

TAKAHASHI, S ^{[1
]}

INUBUSHI, T ^{[1
]}

机构：

[1] SHIGA UNIV MED SCI,MOLEC NEUROBIOL RES CTR,OTSU,SHIGA 52021,JAPAN

来源：

PSYCHIATRY RESEARCH-NEUROIMAGING | 1992年 / 45卷 / 01期

关键词：

AFFECTIVE DISORDER; MANIA; THERAPEUTIC DRUG MONITORING;

D O I：

10.1016/0925-4927(92)90013-T

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A method was developed to measure lithium concentrations in the human brain using in vivo Li-7- and H-1-magnetic resonance spectroscopy (MRS). Lithium concentrations measured by MRS in 10 lithium-treated bipolar patients were at the half level of those measured in serum. Serial measurements indicated that lithium concentrations in the brain increased markedly during manic episodes, while serum concentrations were unchanged. These findings suggest that in vivo measurements of lithium concentrations in the brain, combined with measurements of concentrations in serum, may be useful in monitoring the effects of therapeutic drugs.

引用

页码：53 / 63

页数：11

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