SYNTHESIS OF (1-[2',5'-BIS-O-(T-BUTYLDIMETHYLSILYL)-BETA-D-XYLO AND BETA-D-RIBOFURANOSYL]THYMINE)-3'-SPIRO-5''-(4''-AMINO-1'',2''-OXATHIOLE-2'',2''-DIOXIDE) (TSAO) - A NOVEL TYPE OF SPECIFIC ANTI-HIV AGENTS

被引：41

作者：

PEREZPEREZ, MJ

SANFELIX, A

CAMARASA, MJ

BALZARINI, J

DECLERCQ, E

机构：

[1] INST QUIM MED,JUAN DE LA CIERVA 3,E-28006 MADRID,SPAIN

[2] CATHOLIC UNIV LEUVEN,REGA INST MED RES,B-3000 LOUVAIN,BELGIUM

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 21期

关键词：

NUCLEOSIDES; SPIRO-SUBSTITUTED NUCLEOSIDES; ALDOL-TYPE CYCLOCONDENSATION; ANTI-HIV AGENTS; TSAO;

D O I：

10.1016/S0040-4039(00)79591-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of O-mesylcyanohydrins of furanos-3'-ulosyl thymine with bases afforded beta-D-xylo- and ribo-3'-substituted nucleosides. 2'-Deoxygenation of the selectively 5'-O-protected nucleoside gave the ribofuranosyl derivative of thymidine.

引用

页码：3029 / 3032

页数：4

共 18 条

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