Total synthesis of natural (-)-combretastatin D-1.

被引：20

作者：

Couladouros, EA

Soufli, IC

机构：

[1] Department of Chemistry, Agricultural University of Athens, Athens, 118.55

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 51期

关键词：

D O I：

10.1016/0040-4039(95)01987-S

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Combrestastatin D-1, (2), was synthesized via a 12 step sequence. Sharpless asymmetric dihydroxylation was used in order to introduce the appropriate asymmetry. Regiospecific cyclodehydration of the diol 3 gave the title compound in 96% ee.

引用

页码：9369 / 9372

页数：4

共 13 条

[11] THE OSMIUM-CATALYZED ASYMMETRIC DIHYDROXYLATION - A NEW LIGAND CLASS AND A PROCESS IMPROVEMENT [J].

SHARPLESS, KB ;

AMBERG, W ;

BENNANI, YL ;

CRISPINO, GA ;

HARTUNG, J ;

JEONG, KS ;

KWONG, HL ;

MORIKAWA, K ;

WANG, ZM ;

XU, DQ ;

ZHANG, XL .

JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (10) :2768-2771

[12] ANTINEOPLASTIC AGENTS .206. STRUCTURE OF THE CYTOSTATIC MACROCYCLIC LACTONE COMBRETASTATIN-D-2 [J].

SINGH, SB ;

PETTIT, GR .

JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (09) :2797-2800

[13] PERROTTETIN-E, PERROTTETIN-F, AND PERROTTETIN-G FROM RADULA-PERROTTETII (LIVERWORT) - ISOLATION, STRUCTURE DETERMINATION, AND SYNTHESIS OF PERROTTETIN-E [J].

TOYOTA, M ;

TORI, M ;

TAKIKAWA, K ;

SHIOBARA, Y ;

KODAMA, M ;

ASAKAWA, Y .

TETRAHEDRON LETTERS, 1985, 26 (49) :6097-6100

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