INVIVO BINDING OF N1'-([C-11]METHYL) NALTRINDOLE TO DELTA-OPIOID RECEPTORS IN MOUSE-BRAIN

被引：33

作者：

LEVER, JR

SCHEFFEL, U

KINTER, CM

RAVERT, HT

DANNALS, RF

WAGNER, HN

FROST, JJ

机构：

[1] JOHNS HOPKINS UNIV,DEPT RADIOL,BALTIMORE,MD 21205

[2] JOHNS HOPKINS UNIV,DEPT NEUROSCI,BALTIMORE,MD 21205

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 216卷 / 03期

关键词：

DELTA OPIOID RECEPTORS; NALTRINDOLE; PET (POSITRON EMISSION TOMOGRAPHY);

D O I：

10.1016/0014-2999(92)90448-D

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The regional distribution of N1'-([C-11]methyl)naltrindole ([C-11]MeNTI) in vivo in mouse brain correlates with established delta-opioid receptor densities in vitro. [C-11]MeNTI binding is blocked by naltrindole, a delta-antagonist, but not by cyprodime, a mu-antagonist, of by (+/-)-U50,488, a kappa-agonist. Thus, [C-11]MeNTI selectively labels central delta-opioid receptors in vivo in mouse, and shows promise for positron emission tomography studies of delta sites in human brain.

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收藏

页码：459 / 460

页数：2

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