BIOMEDICAL AND BIOTECHNOLOGICAL APPLICATIONS OF PEG-MODIFIED AND PM-MODIFIED PROTEINS

被引：202

作者：

INADA, Y

FURUKAWA, M

SASAKI, H

KODERA, Y

HIROTO, M

NISHIMURA, H

MATSUSHIMA, A

机构：

[1] Tom Human Science and Technology Center, Department of Materials Science and Technology, Toin University of Yokohama, Aoba-ku, Yokohama, 225

来源：

TRENDS IN BIOTECHNOLOGY | 1995年 / 13卷 / 03期

关键词：

D O I：

10.1016/S0167-7799(00)88912-X

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Chemical modification of proteins and other bioactive molecules with polyethylene glycol (PEG) or its derivatives (PM) can be used to tailor molecular properties to particular applications, eliminating disadvantageous properties or conferring new molecular functions. Complexes of therapeutic proteins and PEG or PM show reduced immunoreactivity, prolonged clearance times and improved biostability. Modification with PEG can also increase the solubility and activity of enzymes in organic solvents, thus extending their potential for application in organic syntheses and biotransformation processes.

引用

页码：86 / 91

页数：6

共 58 条

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