SYNTHESIS OF [5-BIPYRIDYLALANYL(2,2')] GRAMICIDIN-S AND ITS COMPLEXATION WITH DIVALENT METAL-IONS

被引：11

作者：

NISHINO, N ^{[1
]}

ARAI, T ^{[1
]}

HAYASHIDA, J ^{[1
]}

OGAWA, HI ^{[1
]}

YAMAMOTO, H ^{[1
]}

YOSHIKAWA, S ^{[1
]}

机构：

[1] OSAKA NATL RES INST, IKEDA, OSAKA 563, JAPAN

来源：

CHEMISTRY LETTERS | 1994年 / 12期

关键词：

D O I：

10.1246/cl.1994.2435

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A gramicidin S (GS) analog ([Bpa(2,2')]GS), in which the Om residues are replaced by L-5-bipyridylalanines, was synthesized by the solid-phase-synthesis and cyclization-cleavage method. The analog formed stable 1:1 complexes with transition metal ions such as Co2+, Ni2+, Cu2+, and Zn2+ in CH3OH without significant conformational change as shown by the H-1-NMR and circular dichroism analyses. These peptide-metal complexes are water-soluble and will be used in various models of artificial metalloproteins based on the beta-sheet structure.

引用

页码：2435 / 2438

页数：4

共 9 条

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