DBI (DIAZEPAM BINDING INHIBITOR) - THE PRECURSOR OF A FAMILY OF ENDOGENOUS MODULATORS OF GABA-A RECEPTOR FUNCTION - HISTORY, PERSPECTIVES, AND CLINICAL IMPLICATIONS

被引：22

作者：

BARBACCIA, ML ^{[1
]}

BERKOVICH, A ^{[1
]}

GUARNERI, P ^{[1
]}

SLOBODYANSKY, E ^{[1
]}

机构：

[1] GEORGETOWN UNIV,SCH MED,FIDIA GEORGETOWN INST NEUROSCI,WASHINGTON,DC 20007

来源：

NEUROCHEMICAL RESEARCH | 1990年 / 15卷 / 02期

关键词：

affective disorders; DBI; endogenous modulator; GABA[!sub]A[!/sub] receptors; ODN; TTN;

D O I：

10.1007/BF00972206

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biochemical, electrophysiological, and lately, molecular biological techniques have shown that GABAA receptors are heterogeneous supramolecular complexes and can be divided into at least three major subgroups: GABAA1, GABAA2, and GABAA3. They differ mainly in the structural and functional properties of the allosteric modulatory center associated with each one of them. This paper will review the present state of research based on the evidence that DBI (diazepam binding inhibitor) and its natural processing products can selectively modulate GABAergic transmission at different GABAA receptor subtypes. Furthermore, the possibility that the DBI family of peptides represents a novel and meaningful neurochemical correlate for neuropsychiatric pathology, sustained by an alteration of GABAergic transmission, will be discussed. © 1990 Plenum Publishing Corporation.

引用

页码：161 / 168

页数：8

共 50 条

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