A SOLUBLE RECEPTOR FOR INTERLEUKIN-1-BETA ENCODED BY VACCINIA VIRUS - A NOVEL MECHANISM OF VIRUS MODULATION OF THE HOST RESPONSE TO INFECTION

被引：436

作者：

ALCAMI, A

SMITH, GL

机构：

[1] Sir William Dunn School, Pathology University of Oxford Oxford

来源：

CELL | 1992年 / 71卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/0092-8674(92)90274-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vaccinia virus gene B15R is shown to encode an abundant, secretory glycoprotein that functions as a soluble interleukin-1 (IL-1) receptor. This IL-1 receptor has novel specificity since, in contrast with cellular counterparts, it binds only IL-1beta and not IL-1alpha or the natural competitor IL-1 receptor antagonist. The vaccinia IL-1beta receptor is secreted when expressed in a baculovirus system and competitively inhibited binding of IL-1beta to the natural receptor on T cells. Deletion of B15R from vaccinia virus accelerated the appearance of symptoms of illness and mortality in intranasally infected mice, suggesting that the blockade of IL-1beta by vaccinia virus can diminish the systemic acute phase response to infection and modulate the severity of the disease. The IL-1beta binding activity is present in other orthopoxviruses.

引用

收藏

页码：153 / 167

页数：15

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