SWISS POPULATION-DATA ON 3 TETRAMERIC SHORT TANDEM REPEAT LOCI - VWA, HUMTHO1, AND F13A1 - DERIVED USING MULTIPLEX PCR AND LASER FLUORESCENCE DETECTION

被引：18

作者：

HOCHMEISTER, MN ^{[1
]}

JUNG, JM ^{[1
]}

BUDOWLE, B ^{[1
]}

BORER, UV ^{[1
]}

DIRNHOFER, R ^{[1
]}

机构：

[1] FED BUR INVEST ACAD,CTR FORENS SCI RES & TRAINING,QUANTICO,VA 22135

来源：

INTERNATIONAL JOURNAL OF LEGAL MEDICINE | 1994年 / 107卷 / 01期

关键词：

PCR; MULTIPLEX; VWA; HUMTHO1; F13A1; FLUORESCENCE DETECTION; HARDY-WEINBERG EXPECTATIONS; SHORT TANDEM REPEAT LOCI;

D O I：

10.1007/BF01247272

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

Allele and genotype frequencies for 3 tetrameric short tandem repeat loci VWA, HUMTHO1, and F13A1 were determined in a Swiss population sample using multiplex PCR and subsequent electrophoresis in DNA sequencing gels processed by automated laser fluorescence detection. The technique allows single base pair resolution and rapid typing, with a concomitant reduction in the potential for human transcriptional typing errors. All loci meet Hardy-Weinberg expectations. In addition, there is little evidence for association of alleles among the 3 loci. The allelic frequency data can be used in forensic analyses and paternity tests to estimate the frequency of a multiple STR locus DNA profile in the Swiss population.

引用

页码：34 / 36

页数：3

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