IN-PROCESS CONTROL OF INSULIN PRODUCTION BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：7

作者：

MANDRUP, G

机构：

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 1992年 / 11卷 / 10期

关键词：

D O I：

10.1016/0165-9936(92)80030-A

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A well functioning process monitoring system is necessary in the optimization of purification processes, and to maintain the conditions at the optimal level required to secure production of high purity insulin with maximum yield. In our experience, the desired yield and purity can only be reached through improved and expanded analytical control, where reversed-phase high-performance liquid chromatography (RP-HPLC) has a central role. Conditions for the specific RP-HPLC method are described. Chromatograms of actual samples from in-process control of insulin are discussed.

引用

页码：389 / 395

页数：7

共 15 条

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[12]

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