LOCALIZATION OF CANNABINOID RECEPTOR IN THE HUMAN DEVELOPING AND ADULT BASAL GANGLIA - HIGHER LEVELS IN THE STRIATONIGRAL NEURONS

被引：102

作者：

MAILLEUX, P

VANDERHAEGHEN, JJ

机构：

[1] Laboratory of Neurophysiology, Faculty of Medicine, Université Libre de Bruxelles, Brussels

来源：

NEUROSCIENCE LETTERS | 1992年 / 148卷 / 1-2期

关键词：

MARIJUANA; CANNABINOID; CANNABINOID RECEPTOR; RECEPTOR AUTORADIOGRAPHY; INSITU HYBRIDIZATION; HUMAN BASAL GANGLIA; DEVELOPMENT;

D O I：

10.1016/0304-3940(92)90832-R

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the infant and adult human basal ganglia, the finding of mRNA exclusively in the striatal medium-sized neurons together with the detection of [H-3]CP55,940 binding sites in the caudate-putamen, accumbens, substantia nigra pars reticulata and globus pallidus suggests cannabinoid receptor localization on the striatal intrinsic enkephalinergic and substance P-projecting neurons and on their nigral and pallidal terminals. However, the consistent finding of higher binding in the substantia nigra pars reticulata and medial part of the globus pallidus over its lateral segment suggests cannabinoid receptor enrichment on the striatal substance P neurons which express selectively the dopamine D1 receptor.

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页码：173 / 176

页数：4

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