AGING - CAUSES AND DEFENSES

被引：37

作者：

MARTIN, GR

DANNER, DB

HOLBROOK, NJ

机构：

[1] Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore

来源：

ANNUAL REVIEW OF MEDICINE | 1993年 / 44卷

关键词：

SENESCENCE; TELOMERES; MITOCHONDRIAL DNA; HEAT SHOCK RESPONSE;

D O I：

10.1146/annurev.me.44.020193.002223

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Recent studies have shown that chromosomes shorten as cells divide and become senescent. Also, deletions in mitochondrial DNA increase markedly with advancing age, presumably secondary to damage from oxygen radicals. Since host defenses against environmental factors also become attenuated, the molecular damage associated with aging may increasingly perturb normal homeostasis and increase the susceptibility to disease and disability. Such age-associated dysfunctions can be targeted and interrupted.

引用

页码：419 / 429

页数：11

共 45 条

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