DETERMINATION OF SULPHATIAZOLE IN THE PRESENCE OF SULPHAMETAZINE BY 1ST-DERIVATIVE SOLID-PHASE SPECTROPHOTOMETRY

被引：5

作者：

CAPITANVALLVEY, LF ^{[1
]}

DEORBE, I ^{[1
]}

VALENCIA, MC ^{[1
]}

BERZASNEVADO, JJ ^{[1
]}

机构：

[1] UNIV CASTILLA LA MANCHA,DEPT ANALYT CHEM & FOOD TECHNOL,E-13071 CIUDAD REAL,SPAIN

来源：

MIKROCHIMICA ACTA | 1993年 / 111卷 / 4-6期

关键词：

SOLID-PHASE SPECTROPHOTOMETRY; DERIVATIVE SPECTROSCOPY; SULFATHIAZOLE DETERMINATION; PHARMACEUTICAL ANALYSIS;

D O I：

10.1007/BF01245310

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Sulphathiazole in the presence of sulphametazine is determined by a method based on derivative solid-phase spectrophotometry. Both compounds are fixed on a dextran-type cation-exchange gel. The absorbance of the gel, packed in a 1-mm silica cell, is measured directly. The range of application is between 0.20 and 18.0 mug/ml of sulphathiazole in the presence of up to 20 mug/ml of sulphametazine, the relative standard deviation is 0.6% and the detection limit is 0.05 mug/ml. The method has been applied to the determination of sulphathiazole in synthetic mixtures and pharmaceuticals, with recoveries of 95.0 to 102.5%

引用

页码：223 / 229

页数：7