A MAP OF 22 LOCI ON HUMAN CHROMOSOME-22

被引：46

作者：

DUMANSKI, JP

CARLBOM, E

COLLINS, VP

NORDENSKJOLD, M

EMANUEL, BS

BUDARF, ML

MCDERMID, HE

WOLFF, R

OCONNELL, P

WHITE, R

LALOUEL, JM

LEPPERT, M

机构：

[1] KAROLINSKA HOSP,DEPT CLIN GENET,S-10401 STOCKHOLM 60,SWEDEN

[2] KAROLINSKA HOSP,DEPT NEUROSURG,S-10401 STOCKHOLM 60,SWEDEN

[3] UNIV PENN,SCH MED,DEPT HUMAN GENET,PHILADELPHIA,PA 19104

[4] UNIV PENN,SCH MED,DEPT PEDIAT,PHILADELPHIA,PA 19104

[5] CHILDRENS HOSP PHILADELPHIA,DIV HUMAN GENET & MOLEC BIOL,PHILADELPHIA,PA

[6] UNIV ALBERTA,DEPT HUMAN GENET,EDMONTON T6G 2E9,ALBERTA,CANADA

[7] UNIV UTAH,HOWARD HUGHES MED INST,SALT LAKE CITY,UT 84132

[8] UNIV UTAH,DEPT HUMAN GENET,SALT LAKE CITY,UT 84132

来源：

GENOMICS | 1991年 / 11卷 / 03期

关键词：

D O I：

10.1016/0888-7543(91)90079-T

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We constructed a genetic linkage map of the entire long arm of human chromosome 22 with 30 polymorphic markers, defining 22 loci. The map consists of a continuous linkage group 110 cM long, when male and female recombination fractions are combined; average distance between the loci is 5.2 cM. All loci were placed on the map with high support against alternative orders (odds in excess of 1000:1). The order of loci presented in our map is in full agreement with that of the previous linkage maps of chromosome 22 and with the physical assignment of markers. Two markers included in this map, KI-831 (D22S212) and pEFZ31 (D22S32), allowed us to better define the region of the (11;22) translocation breakpoint specific for Ewing sarcoma. Ten additional polymorphic markers were placed on the 22-loci map with odds lower than 1000:1 against alternative locations. In total, we have introduced 29 new markers on the linkage map of chromosome 22. © 1991.

引用

页码：709 / 719

页数：11

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