REDUCTION OF CEREBRAL GLUCOSE-UTILIZATION BY THE HIV ENVELOPE GLYCOPROTEIN-GP-120

被引：30

作者：

KIMES, AS ^{[1
]}

LONDON, ED ^{[1
]}

SZABO, G ^{[1
]}

RAYMON, L ^{[1
]}

TABAKOFF, B ^{[1
]}

机构：

[1] NIAAA,INTRAMURAL RES PROGRAM,SPECIAL PROJECTS UNIT,BETHESDA,MD 20892

来源：

EXPERIMENTAL NEUROLOGY | 1991年 / 112卷 / 02期

关键词：

D O I：

10.1016/0014-4886(91)90073-L

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Gp-120 is a glycoprotein constituent of the human immunodeficiency virus (HIV) envelope. The effects of gp-120 on cerebral glucose utilization in rats were studied by the quantitative 2-deoxy-d-[1-14C]glucose method. Intracerebroventricular injection of gp-120 significantly reduced glucose utilization in the lateral habenula and the suprachiasmatic nucleus and decreased the global cerebral metabolic rate for glucose. The findings suggest that gp-120 and closely related peptides can alter neuronal function, thereby contributing to the sequelae of HIV infection. © 1991.

引用

页码：224 / 228

页数：5

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