PRECISE SEX SELECTED BIRTHS OF MICE FOLLOWING SINGLE-CELL EMBRYO BIOPSY AND Y-LINKED TESTIS-SPECIFIC GENE ANALYSIS

被引：26

作者：

CUI, KH ^{[1
]}

PUTLAND, RA ^{[1
]}

SEAMARK, RF ^{[1
]}

MATTHEWS, CD ^{[1
]}

机构：

[1] QUEEN ELIZABETH HOSP,DEPT CLIN MICROBIOL & INFECT DIS,WOODVILLE,SA 5011,AUSTRALIA

来源：

HUMAN REPRODUCTION | 1993年 / 8卷 / 04期

关键词：

EMBRYO BIOPSY; GENE; IVF; PREIMPLANTATION DIAGNOSIS; SEX;

D O I：

10.1093/oxfordjournals.humrep.a138107

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

We report on the birth of 39 mice following single cell embryo biopsy and precise sex determination following in-vitro fertilization. Polymerase chain reaction was used to amplify fragments of the mouse testis-specific gene sequence (pYMT2/B) on the Y chromosome and the ovary-specific gene (ZP3) sequence on chromosome 5 from the single biopsied cell. Embryo biopsy was not associated with any deleterious effects.

引用

页码：621 / 626

页数：6

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