IN-VITRO AND IN-VIVO EVALUATION OF OXYGEN EFFECTS ON A GLUCOSE-OXIDASE BASED IMPLANTABLE GLUCOSE SENSOR

被引：87

作者：

ZHANG, YN ^{[1
]}

WILSON, GS ^{[1
]}

机构：

[1] UNIV KANSAS,DEPT CHEM,LAWRENCE,KS 66045

来源：

ANALYTICA CHIMICA ACTA | 1993年 / 281卷 / 03期

关键词：

BIOSENSORS; GLUCOSE SENSOR; IMPLANTABLE SENSOR; SUBCUTANEOUS TISSUE;

D O I：

10.1016/0003-2670(93)85009-9

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The oxygen effect on a glucose oxidase based implantable glucose sensor was investigated based on studies of tissue oxygen availability and demand for oxygen by the glucose sensor. In vitro measurements showed that the oxygen effect is directly related to the glucose sensor sensitivity and linearity. Results of in vivo measurements in rat subcutaneous tissue with simultaneously implanted oxygen sensor and glucose sensor also suggested similar influence. A practically useful glucose sensor that is essentially free of oxygen fluctuation can be constructed by controlling its sensitivity and linearity.

引用

页码：513 / 520

页数：8

共 11 条

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