EPIDERMAL GROWTH-FACTOR RECEPTOR AND PROGNOSIS IN HUMAN BREAST-CANCER - A PROSPECTIVE-STUDY

被引：39

作者：

KOENDERS, PG ^{[1
]}

BEEX, LVAM ^{[1
]}

KIENHUIS, CBM ^{[1
]}

KLOPPENBORG, PWC ^{[1
]}

BENRAAD, TJ ^{[1
]}

机构：

[1] UNIV HOSP NIJMEGEN,DEPT MED,DIV ENDOCRINOL,6500 HB NIJMEGEN,NETHERLANDS

来源：

BREAST CANCER RESEARCH AND TREATMENT | 1993年 / 25卷 / 01期

关键词：

HUMAN BREAST CANCER; EPIDERMAL GROWTH FACTOR RECEPTOR; ESTROGEN RECEPTOR; PROGESTERONE RECEPTOR; PROGNOSIS;

D O I：

10.1007/BF00662397

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The prognostic value of Epidermal Growth Factor Receptor (EGFR) in human breast cancer is a matter of debate. We conducted a prospective study that included 459 unselected patients with primary breast cancer (median follow-up 24 months) to assess the prognostic value of EGFR. EGFR was assessed using a standardized radioligand binding assay. Univariate analysis showed that EGFR is a factor indicative of a poor prognosis with respect to Disease Free Survival (DFS, P = 0.03) and Overall Survival (OS, P= 0.002), if an EGFR level of 50 fmol/mg of membrane protein is introduced as a cut-off for EGFR-positivity. Multivariate analysis showed that EGFR was not an independent factor. This prospective study shows that EGFR, although not an independent factor, is indicative of poor prognosis in human breast cancer.

引用

页码：21 / 27

页数：7

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