DOES HIGH MHC CLASS-II GENE-EXPRESSION IN NORMAL LUNGS ACCOUNT FOR THE STRONG IMMUNOGENICITY OF LUNG ALLOGRAFTS

被引：3

作者：

ALWAYN, IPJ

XU, RK

ADLER, WH

KITTUR, DS

机构：

[1] Leiden University Medical School, Leiden, NL-2333 AA

[2] Division of Transplant Surgery, The Johns Hopkins Medical Institutions, Baltimore, 21287, MD, Harvey 805

[3] Gerontology Research Center, NIA, Baltimore, 21287, MD

来源：

TRANSPLANT INTERNATIONAL | 1994年 / 7卷 / 01期

关键词：

LUNG TRANSPLANTATION; MICE; MHC CLASS II EXPRESSION; LUNG; REJECTION;

D O I：

10.1007/BF00335663

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Clinical experience has demonstrated that lung allografts are considerably more immunogenic than liver allografts although both organs contain equivalent amounts of lymphoreticular tissue. Northern blot analysis of MHC class II gene expression in various murine organs with I-AB and I-EB gene-specific oligonucleotide probes revealed that MHC class II expression in lungs is semiquantitatively higher than in the liver and other organs with the exception of the spleen. We conclude that this high MHC class II expression strongly suggests that the lymphoreticular tissue in the lungs is in a state of activation. This may be an important reason for the strong immunogenicity of lung allografts.

引用

页码：43 / 46

页数：4

共 18 条

[11]

Prop J., Wildevuur C.R.H., Nieuwenhuis P., Lung allograft rejection in the rat. II. Specific immunological properties of lung grafts, Transplantation, 40, (1985)

[12]

Prop J., Romaniuk A., Petersen A.H., Wildevuur C.R.H., Nieuwenhuis P., Expression of class II major histocompatibility complex antigens in rat lung allografts, Transplant Proc, 19, (1987)

[13]

Romaniuk A., Prop J., Petersen A.H., Wildevuur C.R.H., Nieuwenhuis P., Expression of class II major histocompatibility complex antigens by bronchial epithelium in rat lung allografts, Transplantation, 44, (1987)

[14]

Taylor P.M., Rose M.L., Yacoub M., Expression of class I and class II MHC antigens in normal and transplanted human lung, Transplant Proc, 21, pp. 451-452, (1989)

[15]

de Waal R.M.W., Bogman M.J.J., Maas C.N., Cornelissen L.M.H., Tax W.J.M., Koene R.A.P., Variable expression of Ia antigens on the vascular endothelium of mouse skin allografts, Nature, 303, (1983)

[16]

von Willebrand E., Petterson E., Abonen J., Hayry P., CMV infection class II antigen expression and human kidney allograft rejection, Transplantation, 45, (1986)

[17]

Xu R., Scott A.F., Adler W.H., Kittur D.S., Allele specific oligonucleotide probes for mouse I-A region and gene: I-A\, Immunol Invest, 19, pp. 235-243, (1990)

[18]

Yousem S.A., Curley J.M., Dauber J., Paradis I., Rabinowich H., Zeevi A., Duquesnoy R., Dowling R., Zenati M., Hardesty R., HLA-class II antigen expression in human beart-lung allografts, Transplantation, 49, pp. 991-995, (1990)

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