THE 56/58 KDA ANDROGEN-BINDING PROTEIN IN MALE GENITAL SKIN FIBROBLASTS WITH A DELETED ANDROGEN RECEPTOR GENE

被引：48

作者：

TRIFIRO, M

GOTTLIEB, B

PINSKY, L

KAUFMAN, M

PRIOR, L

BELSHAM, DD

WROGEMANN, K

BROWN, CJ

WILLARD, HF

TRAPMAN, J

BRINKMANN, AO

CHANG, CS

LIAO, SS

SERGOVICH, F

JUNG, J

机构：

[1] SIR MORTIMER B DAVIS JEWISH HOSP, LADY DAVIS INST, 3755 COTE ST CATHERINE RD, MONTREAL H3T 1E2, QUEBEC, CANADA

[2] MCGILL UNIV, LADY DAVIS INST MED RES, DEPT MED, MONTREAL H3T 1E2, QUEBEC, CANADA

[3] MCGILL UNIV, LADY DAVIS INST MED RES, DEPT PEDIAT, MONTREAL H3A 2T5, QUEBEC, CANADA

[4] MCGILL UNIV, LADY DAVIS INST MED RES, CTR HUMAN GENET, MONTREAL H3A 2T5, QUEBEC, CANADA

[5] UNIV MANITOBA, DEPT BIOCHEM & MOLEC BIOL, WINNIPEG R3E 0W3, MANITOBA, CANADA

[6] UNIV MANITOBA, DEPT HUMAN GENET, WINNIPEG R3E 0W3, MANITOBA, CANADA

[7] STANFORD UNIV, MED CTR, SCH MED, DEPT GENET, STANFORD, CA 94305 USA

[8] ERASMUS UNIV, DEPT PATHOL, 3000 DR ROTTERDAM, NETHERLANDS

[9] ERASMUS UNIV, DEPT BIOCHEM 2, 3000 DR ROTTERDAM, NETHERLANDS

[10] UNIV CHICAGO, DEPT BIOCHEM & MOLEC BIOL, CHICAGO, IL 60637 USA

[11] UNIV CHICAGO, BEN MAY LAB CANC RES, CHICAGO, IL 60637 USA

[12] CHILDRENS HOSP W ONTARIO, CHILDRENS PSYCHIAT RES INST, LONDON N6A 4G5, ONTARIO, CANADA

[13] CHILDRENS HOSP W ONTARIO, DEPT MED GENET, LONDON N6A 4G5, ONTARIO, CANADA

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 1991年 / 75卷 / 01期

关键词：

ANDROGEN RECEPTOR; ANDROGEN-BINDING PROTEIN; ANDROGEN INSENSITIVITY; (HUMAN GENITAL SKIN); (FIBROBLASTS);

D O I：

10.1016/0303-7207(91)90243-L

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Human genital skin fibroblasts (GSF) make a relatively abundant 56/58 kDa protein that binds androgens. The protein shares many properties with the approximately 100 kDa androgen receptor that is encoded by a locus in the q12 region of the X chromosome. It does not appear to be androgen-induced, yet is absent in GSF of most patients with complete androgen insensitivity (CAI). A precursor-product relation with the androgen receptor (AR) protein has been largely excluded; that it may be an unorthodox product of the AR gene has not. The 56/58 kDa protein is made by the GSF of a mentally retarded subject who has CAI because of a complete deletion of the coding portion of the AR gene. Hence, the strong constitutional and statistical correlations that have been demonstrated between the two proteins cannot arise because they share the same gene. The subject's genomic DNA hybridizes normally with 11 single-copy probes from Xq11-Xq13. Therefore, we cannot attribute her mental retardation to a contiguous gene syndrome.

引用

页码：37 / 47

页数：11

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