COMPLEX DYNAMICS IN COUPLED CARDIAC-PACEMAKER CELLS

被引：26

作者：

CAI, DM

LAI, YC

WINSLOW, RL

机构：

[1] JOHNS HOPKINS UNIV,WHITING SCH ENGN,DEPT COMP SCI,BALTIMORE,MD 21205

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT BIOMED ENGN,BALTIMORE,MD 21205

[3] UNIV MINNESOTA,USA,HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55455

来源：

PHYSICAL REVIEW LETTERS | 1993年 / 71卷 / 15期

关键词：

D O I：

10.1103/PhysRevLett.71.2501

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

We investigate the dynamics of a model of electrically coupled pacemaking cardiac sino-atrial node cells. Cell models are biophysically detailed, and include voltage-dependent membrane currents, pump-exchanger currents, and time-varying internal ion concentration changes similar to those seen in real sino-atrial node cells. It is found that at low, yet physiologically realistic coupling conductance values, complex dynamics including chaos can arise. Occurrence of these complex dynamics in coupled pacemaker cells may provide an explanation for the origin of certain cardiac arrhythmias.

引用

页码：2501 / 2504

页数：4

共 30 条

[1] GAP JUNCTIONAL CHANNELS IN ADULT MAMMALIAN SINUS NODAL CELLS - IMMUNOLOCALIZATION AND ELECTROPHYSIOLOGY
ANUMONWO, JMB
WANG, HZ
TRABKAJANIK, E
DUNHAM, B
VEENSTRA, RD
DELMAR, M
JALIFE, J
[J]. CIRCULATION RESEARCH, 1992, 71 (02) : 229 - 239
[2] FUNCTIONAL AND MORPHOLOGICAL ORGANIZATION OF THE RABBIT SINUS NODE
BLEEKER, WK
MACKAAY, AJC
MASSONPEVET, M
BOUMAN, LN
BECKER, AE
[J]. CIRCULATION RESEARCH, 1980, 46 (01) : 11 - 22
[3] Brailove A. A., 1992, International Journal of Bifurcation and Chaos in Applied Sciences and Engineering, V2, P341, DOI 10.1142/S0218127492000331
[4] THE IONIC CURRENTS UNDERLYING PACEMAKER ACTIVITY IN RABBIT SINO-ATRIAL NODE - EXPERIMENTAL RESULTS AND COMPUTER-SIMULATIONS
BROWN, HF
KIMURA, J
NOBLE, D
NOBLE, SJ
TAUPIGNON, A
[J]. PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1984, 222 (1228): : 329 - 347
[5] CAI D, 1992, 1992 COMP CARD P, P579
[6] QUANTITATIVE UNIVERSALITY FOR A CLASS OF NON-LINEAR TRANSFORMATIONS
FEIGENBAUM, MJ
[J]. JOURNAL OF STATISTICAL PHYSICS, 1978, 19 (01) : 25 - 52
[7] Glass L, 1988, CLOCKS CHAOS RHYTHMS
[8] A QUANTITATIVE DESCRIPTION OF MEMBRANE CURRENT AND ITS APPLICATION TO CONDUCTION AND EXCITATION IN NERVE
HODGKIN, AL
HUXLEY, AF
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1952, 117 (04): : 500 - 544
[9] HONJO H, 1992, J PHYSIOL-LONDON, V452, P128
[10] MUTUAL ENTRAINMENT AND ELECTRICAL COUPLING AS MECHANISMS FOR SYNCHRONOUS FIRING OF RABBIT SINO-ATRIAL PACE-MAKER CELLS
JALIFE, J
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1984, 356 (NOV): : 221 - 243

← 1 2 3 →