COMPLEX DYNAMICS IN COUPLED CARDIAC-PACEMAKER CELLS

被引：26

作者：

CAI, DM

LAI, YC

WINSLOW, RL

机构：

[1] JOHNS HOPKINS UNIV,WHITING SCH ENGN,DEPT COMP SCI,BALTIMORE,MD 21205

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT BIOMED ENGN,BALTIMORE,MD 21205

[3] UNIV MINNESOTA,USA,HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55455

来源：

PHYSICAL REVIEW LETTERS | 1993年 / 71卷 / 15期

关键词：

D O I：

10.1103/PhysRevLett.71.2501

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

We investigate the dynamics of a model of electrically coupled pacemaking cardiac sino-atrial node cells. Cell models are biophysically detailed, and include voltage-dependent membrane currents, pump-exchanger currents, and time-varying internal ion concentration changes similar to those seen in real sino-atrial node cells. It is found that at low, yet physiologically realistic coupling conductance values, complex dynamics including chaos can arise. Occurrence of these complex dynamics in coupled pacemaker cells may provide an explanation for the origin of certain cardiac arrhythmias.

引用

页码：2501 / 2504

页数：4

共 30 条

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