AMINO-ACID-SEQUENCE OF A MODIFIED BETA-2-MICROGLOBULIN IN RENAL-FAILURE PATIENT URINE AND LONG-TERM DIALYSIS PATIENT BLOOD

被引：6

作者：

MOMOI, T

SUZUKI, M

TITANI, K

HISANAGA, S

OGAWA, H

SAITO, A

机构：

[1] BIODYNAM RES INST,MIZUHO KU,NAGOYA,AICHI 467,JAPAN

[2] FUJITA HLTH UNIV,SCH MED,INST COMPREHENS MED SCI,DIV BIOMED POLYMER SCI,TOYOAKE,AICHI 47011,JAPAN

来源：

CLINICA CHIMICA ACTA | 1995年 / 236卷 / 02期

关键词：

MODIFICATION; BETA(2)-MICROGLOBULIN; DIALYSIS; RENAL FAILURE;

D O I：

10.1016/0009-8981(95)06039-G

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

We isolated and analyzed beta 2-microglobulin (BM) in urine of two renal failure patients and in ultrafiltrate from long-term dialysis patients, In both groups of patients, we found the native BM with pI 5.7 and some modified BM with pI 5.3. The amino acid sequence of the modified BM was determined and compared with that of the native BM; the N-terminal isoleucine residue was missing and the second glutamine residue was cyclized into pyroglutamic acid in the modified BM.

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收藏

页码：135 / 144

页数：10

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