INHIBITORY EFFECT OF A SINGLE LOCAL PROBUCOL ADMINISTRATION ON NEOINTIMAL FORMATION IN BALLOON-INJURED RAT CAROTID-ARTERY

被引：19

作者：

ISHIZAKA, N

KUROKAWA, K

TAGUCHI, J

MIKI, K

OHNO, M

机构：

[1] TERUMO CO,INST BIOMED SCI,TOKYO,JAPAN

[2] UNIV TOKYO,FAC MED,DEPT INTERNAL MED 1,BUNKYO KU,TOKYO 113,JAPAN

来源：

ATHEROSCLEROSIS | 1995年 / 118卷 / 01期

关键词：

PROBUCOL; BALLOON INJURY; LOCAL ADMINISTRATION;

D O I：

10.1016/0021-9150(95)05592-K

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of this study was to determine whether a single local probucol administration could suppress neointimal formation in balloon-injured rat carotid artery. Rats were divided into four groups: (i) rats receiving no probucol (control group); (ii) rats receiving topical application of 50 mg probucol at the time of ballooning (p-top group); (iii) rats fed chow containing 1% probucol (p-fed group); (iv) rats receiving both topical application of 50 mg probucol and chow containing 1% probucol (p-top/fed group). Although serum total cholesterol levels did not significantly differ between the control and the p-top groups at two weeks after balloon injury, the p-top group had a smaller intimal/medial ratio or intimal area than the control group (0.97 +/- O.11 vs. 0.53 +/- 0.08 or 0.15 +/- 0.02 mm(2) vs. 0.08 +/- 0.02 mm(2) respectively, P < 0.01). Neointimal formation was suppressed to a similar extent in the p-fed group, in which serum total cholesterol level was approximately 40% lower than that in the control group, Thus, a single local delivery of probucol can suppress neointimal formation in balloon-injured rat carotid artery without altering serum lipid level.

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页码：53 / 56

页数：4

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