ARAGUSTEROL-C - A NOVEL HALOGENATED MARINE STEROID FROM AN OKINAWAN SPONGE, XESTOSPONGIA SP, POSSESSING POTENT ANTITUMOR-ACTIVITY

被引：23

作者：

SHIMURA, H

IGUCHI, K

YAMADA, Y

NAKAIKE, S

YAMAGISHI, T

MATSUMOTO, K

YOKOO, C

机构：

[1] TOKYO COLL PHARM,HACHIOJI,TOKYO 19203,JAPAN

[2] TAISHO PHARMACEUT CO LTD,RES CTR,OMIYA,SAITAMA 330,JAPAN

来源：

EXPERIENTIA | 1994年 / 50卷 / 02期

关键词：

MARINE SPONGE; HALOGENATED STEROID; ANTITUMOR SUBSTANCE; XESTOSPONGIA;

D O I：

10.1007/BF01984951

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A novel chlorinated steroid, aragusterol C, was isolated from an Okinawan marine sponge of the genus Xestospongia. The compound strongly inhibited the proliferation of KB cells in vitro, and also showed potent in vivo antitumor activity against L1210 cells in mice. The complete structure of aragusterol C was determined by spectroscopic analysis and X-ray crystallographic analysis.

引用

页码：134 / 136

页数：3

共 4 条

[1] 3 UNPRECEDENTED CHLORO STEROIDS FROM THE MAUI SPONGE STRONGYLACIDON SP - KIHEISTERONE-C, KIHEISTERONE-D, AND KIHEISTERONE-E
CARNEY, JR
SCHEUER, PJ
KELLYBORGES, M
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1993, 58 (12) : 3460 - 3462
[2] MARINE NATURAL-PRODUCTS
FAULKNER, DJ
[J]. NATURAL PRODUCT REPORTS, 1992, 9 (04) : 323 - 364
[3] ARAGUSTEROL-A - A POTENT ANTITUMOR MARINE STEROID FROM THE OKINAWAN SPONGE OF THE GENUS, XESTOSPONGIA
IGUCHI, K
FUJITA, M
NAGAOKA, H
MITOME, H
YAMADA, Y
[J]. TETRAHEDRON LETTERS, 1993, 34 (39) : 6277 - 6280
[4] CHLORINATED WITHANOLIDES FROM WITHANIA-SOMNIFERA AND ACNISTUS-BREVIFLORUS
NITTALA, SS
VANDEVELDE, V
FROLOW, F
LAVIE, D
[J]. PHYTOCHEMISTRY, 1981, 20 (11) : 2547 - 2552

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