VIRAL MUTATIONS, TCR ANTAGONISM AND ESCAPE FROM THE IMMUNE-RESPONSE

被引：46

作者：

FRANCO, A

FERRARI, C

SETTE, A

CHISARI, FV

机构：

[1] UNIV PARMA, CATTEDRA MALATTIE INFETT, I-43100 PARMA, ITALY

[2] CYTEL CORP, SAN DIEGO, CA 92121 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1995年 / 7卷 / 04期

关键词：

D O I：

10.1016/0952-7915(95)80098-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Persistent viruses use several mechanisms to evade the immune response, including the generation of mutations that affect TCR recognition. It has recently been reported that spontaneous mutations at TCR contact sites within individual viral epitopes in certain persistent human viruses can abrogate or antagonize the recognition of the corresponding wild-type epitope, and it has been suggested that such mutations may contribute to viral persistence.

引用

页码：524 / 531

页数：8

共 62 条

[31] ACTIVATION OF T-CELLS BY A TYROSINE KINASE ACTIVATION DOMAIN IN THE CYTOPLASMIC TAIL OF CD3-EPSILON
LETOURNEUR, F
KLAUSNER, RD
[J]. SCIENCE, 1992, 255 (5040) : 79 - 82
[32] LIMA POD, 1993, SCIENCE, V260, P98
[33] CYTOLYTIC T-CELL CYTOTOXICITY IS MEDIATED THROUGH PERFORIN AND FAS LYTIC PATHWAYS
LOWIN, B
HAHNE, M
MATTMANN, C
TSCHOPP, J
[J]. NATURE, 1994, 370 (6491) : 650 - 652
[34] CD8(+) T-CELLS SUPPRESS HUMAN-IMMUNODEFICIENCY-VIRUS REPLICATION BY INHIBITING VIRAL TRANSCRIPTION
MACKEWICZ, CE
BLACKBOURN, DJ
LEVY, JA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (06) : 2308 - 2312
[35] ZETA-PHOSPHORYLATION WITHOUT ZAP-70 ACTIVATION-INDUCED BY TCR ANTAGONISTS OR PARTIAL AGONISTS
MADRENAS, J
WANGE, RL
WANG, JL
ISAKOV, N
SAMELSON, LE
GERMAIN, RN
[J]. SCIENCE, 1995, 267 (5197) : 515 - 518
[36] CD4(+) T-CELLS ARE REQUIRED TO SUSTAIN CD8(+) CYTOTOXIC T-CELL RESPONSES DURING CHRONIC VIRAL-INFECTION
MATLOUBIAN, M
CONCEPCION, RJ
AHMED, R
[J]. JOURNAL OF VIROLOGY, 1994, 68 (12) : 8056 - 8063
[37] HOW DNA VIRUSES PERTURB FUNCTIONAL MHC EXPRESSION TO ALTER IMMUNE RECOGNITION
MCFADDEN, G
KANE, K
[J]. ADVANCES IN CANCER RESEARCH, VOL 63, 1994, 63 : 117 - 209
[38] A NOVEL FORM OF EPSTEIN-BARR-VIRUS LATENCY IN NORMAL B-CELLS IN-VIVO
MIYASHITA, EM
YANG, B
LAM, KMC
CRAWFORD, DH
THORLEYLAWSON, DA
[J]. CELL, 1995, 80 (04) : 593 - 601
[39] MORETTA L, 1994, ADV IMMUNOL, V55, P341
[40] MOSMANN TR, 1989, ANNU REV IMMUNOL, V7, P145, DOI 10.1146/annurev.iy.07.040189.001045

← 1 2 3 4 5 6 7 →