ANTIVIRAL 9-[2-(PHOSPHONOMETHYLTHIO)ALKOXY]PURINES

被引：4

作者：

HARNDEN, MR ^{[1
]}

JENNINGS, LJ ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,GREAT BURGH,EPSOM KT18 5XQ,SURREY,ENGLAND

来源：

ANTIVIRAL CHEMISTRY & CHEMOTHERAPY | 1993年 / 4卷 / 04期

关键词：

D O I：

10.1177/095632029300400404

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of 9-[2-(phosphonomethylthio)alkoxy]purine analogues of recently reported antiviral 9-[2-(phosphonomethoxy)alkoxy]purines (Duckworth et al., 1991) has been prepared and evaluated as antiviral agents. 9-[2-(Phosphonomethylthio)ethoxy]guanine (8) has potent activity against herpesviruses, and (R)-9-[3-hydroxy-2-(phosphonomethylthio)propoxy]guanine (37) has potent and selective activity against visna virus and good activity against HIV-1.

引用

页码：215 / 227

页数：13

共 10 条

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