OXYGEN-FREE RADICALS, MELATONIN, AND AGING

被引:115
作者
PIERREFICHE, G [1 ]
LABORIT, H [1 ]
机构
[1] HOSP BOUCICAUT, EUTONOL LAB, F-75730 PARIS 15, FRANCE
关键词
AGING; STRESS; BEHAVIOR; OXYGEN-TREE RADICALS; MELATONIN; ANTIOXIDANT ACTIVITY;
D O I
10.1016/0531-5565(94)00036-3
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
The recognized peripheral and central biochemical, neuroendocrinological, behavioral, pharmacological, and clinical actions of melatonin are involved at different levels of an overall concept of the pathophysiology of aging. This conceptual approach combines the biochemistry of oxygen free radicals, the social behavior of the individual and the resulting cellular alterations. This has allowed us to propose antioxidant properties of melatonin that we have experimentally demonstrated.
引用
收藏
页码:213 / 227
页数:15
相关论文
共 75 条
  • [41] Lakin, Miller, Scott, Winters, Involvement of the pineal gland and melatonin in murine analgesia, Life Sci., 29, pp. 2543-2551, (1981)
  • [42] Leach, Thornburn, A comparison of the inhibitory effects of melatonin and indomethacin on platelet aggregation and thromboxane release, Prostaglandins, 20, pp. 51-56, (1980)
  • [43] Leterrier, Laborit, Essai d'interprétation du mécanisme d'action métabolique de la sérotonine, Agressologie, 5, pp. 153-161, (1964)
  • [44] Lobo, Limaos, Inflammatory response modulated by pinealectomy: Effect of light, Brazilain Med. Biol. Res., 24, pp. 1159-1162, (1991)
  • [45] McEwen, Gould, Adrenal steroid influences on the survival of hippocampal neurons, Biochem. Pharmacol., 40, pp. 2393-2402, (1990)
  • [46] Maestroni, The immunoneuroendocrine role of melatonin, J. Pineal Res., 14, pp. 1-10, (1993)
  • [47] Maestroni, Conti, Pierpaoli, Role of the pineal gland in immunity, Circadian synthesis and release of melatonin modulates the antibody response and antagonizes the immunosuppressive effect of corticosterone, 13, pp. 19-30, (1986)
  • [48] Maestroni, Conti, Pierpaoli, Pineal melatonin, its fundamental immunoregulatory role in aging and cancer, Ann. NY Acad Sci., 521, pp. 140-148, (1988)
  • [49] Maestroni, Conti, Pierpaoli, Melatonin, stress, and the immune system, Pineal Res. Rev., 7, pp. 203-226, (1989)
  • [50] Mendola, Wright, Lacy, Oxygen free-radical scavengers and immune destruction of murine islets in allograft rejection and multiple low-dose streptozocin-induced insulitis, Diabetes, 38, pp. 379-385, (1989)