EFFECT OF GANGLIOSIDES IN THE AUTOIMMUNE-RESPONSE INDUCED BY LIPOSOME-ASSOCIATED ANTIGENS

被引：3

作者：

CORREA, SG ^{[1
]}

RIVERO, VE ^{[1
]}

YRANZOVOLONTE, N ^{[1
]}

ROMEROPIFFIGUER, M ^{[1
]}

FERRO, ME ^{[1
]}

RIERA, CM ^{[1
]}

机构：

[1] NATL UNIV CORDOBA,DEPT BIOQUIM CLIN,CIUDAD UNIV SUC 16,CC 61,RA-5016 CORDOBA,ARGENTINA

来源：

AUTOIMMUNITY | 1993年 / 15卷 / 03期

关键词：

AUTOIMMUNITY; GANGLIOSIDES; RAT MALE ACCESSORY GLANDS;

D O I：

10.3109/08916939309019927

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A model of autoimmunity to rat male accessory glands (RAG) was recently developed by intraperitoneal administration of three doses of native RAG associated with liposomes. In this work we analysed the effects of gangliosides in the cellular response to RAG when they were intraperitoneally administrated prior to the second dose of liposome-associated RAG. Results show that the ganglioside treatment could modify an established DTH response. Also, gangliosides markedly reduced the number of la antigen-positive peritoneal exudated cells (PEC). However, they modified neither the processing of liposomes through PEC nor their viability. Moreover, we obtained cellular response by transferring PEC from immunized donors into naive receptors.

引用

页码：195 / 200

页数：6

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