NEW GLYCOLIPIDS (CHITOOLIGOSACCHARIDE DERIVATIVES) POSSESSING IMMUNOSTIMULATING AND ANTITUMOR ACTIVITIES

被引：35

作者：

GORBACH, VI ^{[1
]}

KRASIKOVA, IN ^{[1
]}

LUKYANOV, PA ^{[1
]}

LOENKO, YN ^{[1
]}

SOLOVEVA, TF ^{[1
]}

OVODOV, YS ^{[1
]}

DEEV, VV ^{[1
]}

PIMENOV, AA ^{[1
]}

机构：

[1] RUSSIAN ACAD MED SCI,CTR ONCOL,MOSCOW,RUSSIA

来源：

CARBOHYDRATE RESEARCH | 1994年 / 260卷 / 01期

关键词：

D O I：

10.1016/0008-6215(94)80023-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

New glycolipids, derived from chitooligosaccharides of dp 2-4 and containing both free and acylated amino groups, were synthesized. The structure of the key compounds (di-, tri-, and tetra-saccharides acylated with different fatty acids) were elucidated by C-13 NMR spectroscopy. Only the amino group of the reducing end of the chitooligosaccharides was found to be acylated when equimolecular amounts of reagents were used. The compounds obtained were shown to possess a low toxicity and certain immunostimulatory and antitumor activities. An induction of interleukin-1 and tumor necrosis factor by the immunocompetent cells and an augmentation by 140-180% of the mean life of mice with the Erlich carcinoma were observed.

引用

页码：73 / 82

页数：10

共 18 条

[1] C-13 NUCLEAR MAGNETIC-RESONANCE DATA FOR OLIGOSACCHARIDES [J].