STRUCTURE AND EVOLUTION OF INSULINS - IMPLICATIONS FOR RECEPTOR-BINDING

被引：86

作者：

MURRAYRUST, J ^{[1
]}

MCLEOD, AN ^{[1
]}

BLUNDELL, TL ^{[1
]}

WOOD, SP ^{[1
]}

机构：

[1] UNIV LONDON BIRKBECK COLL,DEPT CRYSTALLOG,IMPERIAL CANC RES FUND,STRUCT MOLEC BIOL UNIT,LONDON WC1E 7HX,ENGLAND

来源：

BIOESSAYS | 1992年 / 14卷 / 05期

关键词：

D O I：

10.1002/bies.950140507

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Insulin is a member of a family of hormones, growth factors and neuropeptides which are found in both vertebrates and invertebrates. A common 'insulin fold' is probably adopted by all family members. Although the specificities of receptor binding are different, there is a possibility of co-evolution of polypeptides and their receptors.

引用

页码：325 / 331

页数：7

共 45 条

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