TEMPORAL CHANGES IN TRICHURIS-TRICHIURA INFECTION INTENSITY AND SERUM ISOTYPE RESPONSES IN CHILDREN

被引：6

作者：

NEEDHAM, CS

LILLYWHITE, JE

DIDIER, JM

BIANCO, AE

BUNDY, DAP

机构：

[1] UNIV LONDON IMPERIAL COLL SCI & TECHNOL,WELLCOME RES CTR,DEPT BIOL,LONDON SW7 2BB,ENGLAND

[2] UNIV LIVERPOOL,LIVERPOOL SCH TROP MED,LIVERPOOL L3 5QA,ENGLAND

[3] UNIV ST LUCIA CTR,PARASITE EPIDEMIOL PROJECT,CASTRIES,ST LUCIA

来源：

PARASITOLOGY | 1994年 / 109卷

基金：

英国惠康基金;

关键词：

TIME; TRICHURIS TRICHIURA; ISOTYPE RESPONSES; LONGITUDINAL STUDY; CHILDREN;

D O I：

10.1017/S0031182000076307

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The present study describes Trichuris trichiura infections in a cohort of children over a period of approximately 5 years, and examines the relationships between changes in infection intensity and changes in parasite-specific isotype responses (measured by ELISA). The decrease in mean infection intensity with time was mirrored by time-dependent changes in IgG subclass responses, with IgA and IgE levels remaining relatively constant in the cohort. At the individual level, changes in infection intensity between the initial and final time-points correlated positively and significantly with changes in all isotype levels with the exception of IgA.

引用

页码：197 / 200

页数：4

共 8 条

[1] IMMUNO-EPIDEMIOLOGY OF HUMAN GEOHELMINTHIASIS - ECOLOGICAL AND IMMUNOLOGICAL DETERMINANTS OF WORM BURDEN [J].