SYNTHESIS OF (3S,4S)-4-HYDROXY-2,3,4,5-TETRAHYDROPYRIDAZINE-3-CARBOXYLIC ACID, COMPONENT OF LUZOPEPTIN-A

被引：24

作者：

GRECK, C

BISCHOFF, L

GENET, JP

机构：

[1] Laboratoire de synthèse organique (U.A. 1381), Ecole Nationale Supérieure de Chimie de Paris, 75231 Paris Cédex 05

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 08期

关键词：

D O I：

10.1016/0957-4166(95)00258-Q

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The enantioselective synthesis of (3S, 4S)4-hydroxy-2, 3, 4, 5-tetrahydropyridazine-3-carboxylic acid 1 is described. The two stereogenic centers in anti relationship are obtained by sequential enantio and chemoselective hydrogenation of beta-ketoester in presence of chiral ruthenium catalyst and diastereoselective amination of beta-hydroxyester with di t-butylazodicarboxylate.

引用

页码：1989 / 1994

页数：6

共 13 条

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