ANTIBODY-INDUCED DOWN-REGULATION OF A MUTATED INSULIN-RECEPTOR LACKING AN INTACT CYTOPLASMIC DOMAIN

被引：12

作者：

MORGAN, DO

ELLIS, L

RUTTER, WJ

ROTH, RA

机构：

[1] STANFORD UNIV,MED CTR,SCH MED,DEPT PHARMACOL,STANFORD,CA 94305

[2] UNIV CALIF SAN FRANCISCO,HORMONE RES INST,SAN FRANCISCO,CA 94143

来源：

BIOCHEMISTRY | 1987年 / 26卷 / 11期

关键词：

D O I：

10.1021/bi00385a001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：2959 / 2963

页数：5

共 26 条

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[2]

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[3] THE HUMAN INSULIN-RECEPTOR CDNA - THE STRUCTURAL BASIS FOR HORMONE-ACTIVATED TRANSMEMBRANE SIGNALING [J].

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ELLIS, L ;

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OU, JH ;

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GOLDFINE, ID ;

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RUTTER, WJ .

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[4] EXPRESSION OF A FUNCTIONAL HUMAN INSULIN-RECEPTOR FROM A CLONED CDNA IN CHINESE-HAMSTER OVARY CELLS [J].

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ELLIS, L ;

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ROTH, RA ;

RUTTER, WJ .

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[5] REPLACEMENT OF INSULIN-RECEPTOR TYROSINE RESIDUES 1162 AND 1163 COMPROMISES INSULIN-STIMULATED KINASE-ACTIVITY AND UPTAKE OF 2-DEOXYGLUCOSE [J].

ELLIS, L ;

CLAUSER, E ;

MORGAN, DO ;

EDERY, M ;

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RUTTER, WJ .

CELL, 1986, 45 (05) :721-732

[6]

GAVIN JR, 1974, P NATL ACAD SCI USA, V71, P84, DOI 10.1073/pnas.71.1.84

[7] ANTIBODY AGAINST THE INSULIN-RECEPTOR CAUSES DISAPPEARANCE OF INSULIN-RECEPTORS IN 3T3-L1 CELLS - A POSSIBLE EXPLANATION OF ANTIBODY-INDUCED INSULIN RESISTANCE [J].

GRUNFELD, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (08) :2508-2511

[8]

HEDO JA, 1984, J BIOL CHEM, V259, P1083

[9]

KAHN CR, 1979, P SOC EXP BIOL MED, V162, P13

[10]

KAHN CR, 1985, ANNU REV MED, V36, P429

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