CLONING AND SEQUENCE-ANALYSIS OF A CDNA-ENCODING HUMAN NONSELECTIVE TYPE OF ENDOTHELIN RECEPTOR

被引：115

作者：

NAKAMUTA, M

TAKAYANAGI, R

SAKAI, Y

SAKAMOTO, S

HAGIWARA, H

MIZUNO, T

SAITO, Y

HIROSE, S

YAMAMOTO, M

NAWATA, H

机构：

[1] TOKYO INST TECHNOL,DEPT BIOL SCI,MEGURO KU,TOKYO 152,JAPAN

[2] NATL DEF MED COLL,DEPT BIOCHEM 2,TOKOROZAWA,SAITAMA 359,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 177卷 / 01期

关键词：

D O I：

10.1016/0006-291X(91)91944-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A cDNA encoding non-selective type (ETB) of endothelin receptor was isolated from a human liver cDNA library. The cDNA had an open reading frame encoding a protein of 442 amino acid residues with a relative Mr of 49,643. The deduced amino acid sequence of human ETB receptor was 88% and 64% identical to those of rat lung ETB receptor and bovine lung ET-1-specific (ETA) receptor, respectively, and contained a relatively long and proline-rich extracellular N-terminal region in addition to a significant similarity with the G protein-coupled receptor super-family with seven transmembrane segments. © 1991.

引用

页码：34 / 39

页数：6